Brandon Murray came off the bench to score a team-high 21 points, and 12th-seeded McNeese pulled off the first major upset of the NCAA Tournament, eliminating fifth-seeded Clemson 69-67 in a first-round Midwest Region matchup Thursday in Providence, R.I.Quadir Copeland added 16 points, seven rebounds and five assists for the Cowboys (28-6), who advanced to a second-round contest on Saturday against No. 4 Purdue, which knocked out High Point 75-63.Christian Shumate added 13 points and 11 rebounds, while Sincere Parker contributed 12 points in a reserve role. McNeese led by 24 points with 16:14 left in the game, building the enormous lead thanks to a 15-0 advantage in points off turnovers during the first half and a 44-24 margin in points in the paint on the day.Jaeden Zackery scored a game-high 24 points and Chase Hunter added 21 — all in the final 10:02 — to pace the Tigers (27-7). But second-leading scorer Ian Schieffelin missed all four shots he tried and finished with just one point, 11.8 below his average.No. 1 Houston 78, No. 16 SIU Edwardsville 40Milos Uzan scored 14 of his 16 points in the first half to help the top-seeded Cougars cruise by the SIUE Cougars in Midwest Region first-round play in Wichita, Kan.L.J. Cryer scored all 15 points in the first half and Ja’Vier Francis had 13 points and eight rebounds as Houston (31-4) won its 14th straight game on the way to a second-round matchup with No. 8 Gonzaga on Saturday.SIU Edwardsville star Ray’Sean Taylor scored 10 points on 3-of-13 shooting. Taylor finished his career with a school-record 1,962 points. His cousin, Brian Taylor, also had 10 points for Edwardsville, which qualified for its first NCAA Tournament appearance by winning the Ohio Valley Conference postseason tournament.No. 2 Tennessee 77, No. 15 Wofford 62Chaz Lanier put up 29 points, Zakai Zeigler added 12 points and 12 assists and the Volunteers advanced to the second round of the Midwest Region with a win over the Terriers in Lexington, Ky.Jahmai Mashack had nine points and seven rebounds for Tennessee (28-7), which will face No. 7 UCLA in the second round on Saturday.Jackson Sivills had 15 points and five boards for Wofford (19-16), Corey Tripp scored 14 points and Jeremy Lorenz finished with 12.No. 4 Purdue 75, No. 13 High Point 63Trey Kaufman-Renn poured in 21 points, Braden Smith added 20 with six assists and the Boilermakers gritted out a victory over the Panthers in the first round in Providence, R.I.Kaufman-Renn shot 10-for-16 and had eight rebounds to guide Purdue (23-11). Camden Heide added an 11-point, 10-rebound double-double for Purdue, which will face No. 12 McNeese in the second round of the Midwest Region on Saturday.D’Maurian Williams scored 12 points and Trae Benham added 11 to pace High Point (29-6). The Big South champion entered its first NCAA Tournament in program history on a 14-game winning streak.No. 7 UCLA 72, No. 10 Utah State 47Skyy Clark and Eric Dailey Jr. scored 14 points apiece to lead the Bruins to an easy win over the Aggies in a Midwest Region contest.Clark led a sharp-shooting display by the Bruins (23-10), who were 10-for-24 from 3-point range and advanced to face No. 2 Tennessee in the second round on Saturday.Mason Falslev led the Aggies (26-8) with 17 points and 10 rebounds while Deyton Albury added 12 points and seven boards.No. 8 Gonzaga 89, No. 9 Georgia 68The Bulldogs raced out to a 27-3 lead out of the gate and coasted to a first-round win over Georgia in the Midwest Region in Wichita, Kan.Khalif Battle had 24 points and eight rebounds to lead Gonzaga (26-8), which will play No. 1 Houston on Saturday. Braden Huff added 18 points and eight boards for the Bulldogs, who won their 16th straight first-round game. Nolan Hickman chipped in with 18 points.Georgia (20-13) was led by Asa Newell’s 20 points and eight rebounds, while Silas Demary Jr. contributed 15 points. Blue Cain and Somto Cyril finished with 10 points apiece.West RegionNo. 2 St. John’s 85, No. 15 Omaha 53RJ Luis Jr. made a career-high five 3-pointers and the Red Storm found their shooting stroke en route to a victory over Omaha in Providence, R.I.St. John’s (31-4) earned its first tournament win since 2000. Coach Rick Pitino and the Big East champs will face John Calipari and No. 10 seed Arkansas in the second round Saturday. Luis led all scorers with 22 points and added eight rebounds. Simeon Wilcher scored 13 points for the Red Storm. Kadary Richmond had 10 points, eight rebounds and six assists, while Zuby Ejiofor added 10 points, seven boards, four assists and three blocks.JJ White posted 15 points and five assists to lead Omaha (22-13), which was playing in its first NCAA Tournament after claiming the Summit League championship.No. 11 Drake 67, No. 6 Missouri 57Bennett Stirtz had 21 points and four assists as the Bulldogs upset the Tigers in Wichita, Kan.Tavion Banks added 15 points for the Bulldogs (31-3), who will face No. 3 Texas Tech on Saturday. After Missouri trimmed the deficit to 52-51 with 4:28 to play, Stirtz hit a jumper and Cam Manyawu scored inside to keep Missouri at bay. Banks then threw down a transition dunk with 58 seconds left to ice the game.Caleb Grill scored 14 points and Tamar Bates added 10 for the Tigers (22-12).No. 10 Arkansas 79, No. 7 Kansas 72Jonas Aidoo scored a game-high 22 points and the Razorbacks canned eight straight foul shots in the final minute to clinch a win over the Jayhawks in Providence, R.I.Johnell Davis added 18 points, including two free throws with 10.4 seconds left for a 77-72 advantage. D.J. Wagner scored 14 points and dished out six assists, while Trevor Brazile chipped in an 11-point, 12-rebound double-double. The Razorbacks (21-13) advance to a second-round matchup on Saturday against St. John’s.Zeke Mayo scored 18 points to lead Kansas (21-13), while AJ Storr came off the bench to add 15. KJ Adams hit for 13 points and Hunter Dickinson contributed 11.No. 3 Texas Tech 82, No. 14 UNC Wilmington 72Kerwin Walton established career bests of 27 points and eight 3-pointers to lead the Red Raiders past the Seahawks in West Region first-round play in Denver.Elijah Hawkins added 14 points, 10 assists and nine rebounds for Texas Tech (26-8), which will face No. 11 Drake in Saturday’s second round. Darrion Williams had 13 points and nine boards, and JT Toppin added 12 points and 11 rebounds.Nolan Hodge has 18 points and seven rebounds for UNC Wilmington (27-8), which is 1-7 all-time in NCAA Tournament play. Bo Montgomery added 10 points for the Seahawks.